کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
229856 465052 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Extractive-spectrophotometric methods for determination of anti-Parkinsonian drug in pharmaceutical formulations and in biological samples using sulphonphthalein acid dyes
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Extractive-spectrophotometric methods for determination of anti-Parkinsonian drug in pharmaceutical formulations and in biological samples using sulphonphthalein acid dyes
چکیده انگلیسی

A simple, accurate and highly sensitive spectrophotometric methods are proposed for the rapid and accurate determination of amantadine HCl (AMD) using bromocressol green (BCG), bromophenol blue (BPB) and bromothymol blue (BTB). The developed methods involve formation of stable yellow colored chloroform extractable ion-associate complexes of the amino derivative (basic nitrogen) of the AMD with three sulphonphthalein acid dyes, namely; BCG, BPB and BTB, in acidic medium. The ion-associates exhibit absorption maxima at 415, 412 and 414 nm for BCG, BPB and BTB, respectively. AMD can be determined up to 1.5–16.5, 1.4–14.0 and 1.6–17 μg mL−1, respectively. The effect of optimum conditions via acidity, reagent concentration, time, and solvent was studied. The stoichiometry of the reaction was found to be 1:1 in all cases. The low relative standard deviation values indicate good precision and high recovery values. These methods have been successfully applied for the assay of AMD in pharmaceutical formulations. Statistical comparison of the results with the reference method shows excellent agreement and indicates no significant difference in accuracy and precision.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Saudi Chemical Society - Volume 16, Issue 1, January 2012, Pages 75–81
نویسندگان
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