Design and construction of polymerized-glucose coated Fe3O4 magnetic nanoparticles for delivery of aspirin

This study demonstrates a facile but effective method to construct glucose coated magnetic Fe3O4 nanoparticles for drug delivery through a glycothermal method (100–200 °C). In this process, magnetic Fe3O4 nanoparticles were firstly prepared via a glycothermal reaction of Fe (III) salts (e.g., FeCl3·6H2O) in ethylene glycol. Second, the polymerized glucose was used as a carbon layer to coat on the surface of Fe3O4 nanoparticles. The polymerized glucose layer is biocompatible and can provide functional –OH groups for interaction with biomolecules that contain –COOH, –SH, and –NH2 groups. The particle characteristics (morphology, size, surface property) were identified by various techniques such as transmission electron microscopy (TEM), Fourier transform infrared (FT-IR) spectroscopy, and ultraviolet visible (UV–vis) spectrum. Finally, the polymerized-glucose coated magnetic Fe3O4 nanocomposites were used in drug delivery test at ambient conditions, and the loading or release performance of aspirin was assessed by using UV–vis spectroscopy. The influence of pH and ionic strength on the adsorption capacity has also been investigated. The findings in this study will be useful for engineering iron oxide nanoparticles for potential drug delivery applications.

This study demonstrates a facile but effective glycothermal method (100–200 °C) method to synthesize polymerized glucose coated magnetic Fe3O4 nanoparticles for drug delivery of aspirin. The drug loading and release process are well controlled. The findings in this study will be useful for engineering iron oxide nanoparticles for potential drug delivery applications.Figure optionsDownload as PowerPoint slideHighlights
► Fe3O4@polymerized glucose core/shell nanocomposites were synthesized.
► The magnetic nanocomposites exhibited a good loading capacity for aspirin.
► Different drug release media have been investigated in details.
► The possible mechanism for aspirin loading and release is proposed.