Application of SBA-15 mesoporous material as the carrier for drug formulation systems. Papaverine hydrochloride adsorption and release study

SBA-15 mesoporous material was used as a matrix in three different drug formulations (powders, granules and tablets). Hydroxypropyl cellulose (HPC) and stearic acid (SA) were applied as modifiers of papaverine hydrochloride release from mesoporous carriers. The samples were characterized by thermogravimetry, differential scanning calorimetry (DSC), X-ray diffraction (XRD) and nitrogen sorptometry at − 196 °C. High pressure applied during the drug formulation (granules, tablets) decreases both specific surface area and porosity of SBA-15. The changes in BET surface area were also observed after drug deposition. The Korsmeyer–Peppas model was applied to evaluate the kinetics of papaverine hydrochloride release from hydroxypropyl cellulose- and stearic acid-containing drug formulations. The extended drug release resulted from slow diffusion of the active substance from micro- and mesoporous channels blocked by hydrophobic stearic acid and organic polymer.

Schematic representation of papaverine hydrochloride release from mesoporous channel.Figure optionsDownload as PowerPoint slideHighlights
► Possibility of application of SBA-15 as the carrier for papaverine.
► Search for the best formulation of the studied systems (carrier–drug).
► Prolongation of drug release process by appropriate formulation.
► Influence of preparation of SBA-15-papaverine systems on kinetics of drug release.