کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
237231 465698 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Unique indomethacin nanoparticles formation by cogrinding with dextrin under defined moisture conditions
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Unique indomethacin nanoparticles formation by cogrinding with dextrin under defined moisture conditions
چکیده انگلیسی

Indomethacin (IMC) nanoparticles were formed by cogrinding with dextrin under defined moisture conditions. We investigated the mechanism by which IMC nanoparticles are formed and the factors affecting their formation. Cogrinding of IMC and dextrin with optimal water content yielded more than 60% nanoparticles with an average size of 100–200 nm in aqueous solution. Mixtures ground in dry or higher moisture conditions yielded a lower proportion of IMC nanoparticles. The water content producing maximum yields of nanoparticles varied depending on the weight ratio of dextrin to IMC, and the molecular weight of dextrin. Powder X-ray diffraction and solid-state NMR measurements demonstrated that the molecular state of IMC in ground mixture (GM) of IMC and dextrin at suitable moisture condition was mostly crystalline, while that of GM at dry condition was a mixture of amorphous and crystalline forms. The morphology of nanoparticles observed by atomic force microscopy in aqueous solution was soft at the outer surface, suggesting dextrin may adsorb on the IMC nanocrystal surface. Water during grinding could facilitate the dispersion of nanocrystalline IMC into the dextrin matrix. The effective adsorption and interaction of dextrin on the IMC nanocrystal surface could inhibit the aggregation after dispersing in water.

When indomethacin and dextrin are coground under suitable moisture conditions, indomethacin in ground mixture (GM) exists in crystalline form. Adsorption of dextrin occurs at the outer surface of nanocrystalline IMC and the interaction between indomethacin and dextrin occur through the water molecules. After dispersing into water, the primary particles (~50 nm) might aggregate to form secondary particles (~150 nm).Figure optionsDownload as PowerPoint slideHighlights
► Dextrin was used as a cogrinding additive for preparing indomethacin nanoparticles.
► Mechanism and factors affecting nanoparticle formation were investigated.
► Water during cogrinding plays an important role in drug nanoparticle formation.
► Adsorption of dextrin occurs at the outer surface of nanocrystalline indomethacin.
► Interactions between indomethacin and dextrin occur through the water molecules.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Powder Technology - Volume 221, May 2012, Pages 213–219
نویسندگان
, , , , , ,