کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2395475 1101573 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nutritional Programming of Intrauterine Development: A Concept Applicable to the Horse?
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Nutritional Programming of Intrauterine Development: A Concept Applicable to the Horse?
چکیده انگلیسی

Human epidemiological observations and studies of experimental animals have shown that low birth weight is associated with adult phenotypes characterized by abnormalities in cardiovascular, metabolic, and endocrine function. In human populations, these changes can lead to overt degenerative diseases such as hypertension and type 2 diabetes. Because fetal growth depends primarily on the nutrient supply, the associations between birth weight and adult phenotype have been linked to poor nutrition in utero. The fetal supply of nutrients and oxygen depends on both the availability of these substances in the mother and the functional capacity of the placenta to supply them to the fetus. This review takes a comparative approach to examining the nutritional programming of adult physiological phenotype in mammals with emphasis on the horse where possible. It considers the role of maternal nutritional state and placental function in these processes and discusses the cellular and molecular mechanisms operating in utero that are responsible for the epigenetic regulation of phenotypical diversity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Equine Veterinary Science - Volume 33, Issue 5, May 2013, Pages 295–304
نویسندگان
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