Effects of alpha-casozepine (Zylkene) versus selegiline hydrochloride (Selgian, Anipryl) on anxiety disorders in dogs

After a first study showing efficacy on anxiety disorders in cats, the putative effects of alpha-casozepine (a tryptic bovine αs1-casein hydrolysate) on anxious disorders in dogs was investigated. The trial was conducted against a control molecule, selegiline. Thirty-eight dogs were recruited within veterinary practices by certified behaviorist surgeons. This 56 day trial, against the reference molecule, selegiline, showed that both products were efficient to decrease the EDED score and no statistical difference was found between their success score. Owners assessment was also statistically perfectly equivalent. Due to this efficacy, and to its safety, alpha-casozepine (Zylkene) should be considered an option by the veterinary surgeon for the biological management of anxiety beside the compulsory behavior modifications.