کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2461400 1555018 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Goats challenged with different members of the Mycobacterium tuberculosis complex display different clinical pictures
ترجمه فارسی عنوان
گوسفندان با اعضای مختلفی از مجموعه میکروسکوپیک توبرکلوزیس به نمایش در می آیند
کلمات کلیدی
سلول های حیوانی، بز بز نمره ضایعه، ریختن ژنوتیپ تنش
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
چکیده انگلیسی

Tuberculosis (TB) in goats (Capra hircus) is due to infection with members of the Mycobacterium tuberculosis complex (MTC), mainly Mycobacterium bovis and Mycobacterium caprae. We report a comparative experimental infection of goats with M. bovis, M. caprae and M. tuberculosis strains. We hypothesized that goats experimentally infected with different members of the MTC would display different clinical pictures. Three groups of goats were challenged with either M. bovis SB0134 (group 1, n = 5), M. caprae SB0157 (group 2, n = 5) and M. tuberculosis SIT58 (group 3, n = 4). The highest mean total lesion score was observed in M. bovis challenged goats (mean 15.2, range 9–19), followed by those challenged with M. caprae (10.8, 2–23). The lowest score was recorded in goats challenged with M. tuberculosis (3, 1–6). Culture results coincided with the lesion scores in yielding more positive pools (7/15) in M. bovis challenged goats. By contrast, only three pools were positive from goats challenged M. tuberculosis (3/12) and with M. caprae (3/15), respectively. Differences in the performance of the intradermal and gamma-interferon (IFN-γ) tests depending of the group were observed since all goats from group 1 were diagnosed using intradermal test and these goats reacted earlier to the IFN-γ assay in comparison to the other groups. This study confirmed that goats experimentally infected with different members of the MTC display different clinical pictures and this fact may have implications for MTC maintenance and bacterial shedding.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Immunology and Immunopathology - Volume 167, Issues 3–4, 15 October 2015, Pages 185–189
نویسندگان
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