کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2461470 1555026 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expression profiles of antiviral response genes in chicken bursal cells stimulated with Toll-like receptor ligands
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Expression profiles of antiviral response genes in chicken bursal cells stimulated with Toll-like receptor ligands
چکیده انگلیسی

Cells of the adaptive immune system express Toll-like receptors (TLRs) and are able to respond to TLR ligands. With this in mind, the goal of the current study was to determine the expression of antiviral response genes in the cells of the chicken bursa of Fabricius (BF) to stimulation with TLR ligands. We investigated initially the response of bursal B cells to CpG-ODN, lipopolysaccharide (LPS) and poly(I:C) treatment. The expression level of type I interferons (IFNs) and interferon regulatory factor 7 (IRF7) did not differ between CpG-ODN and LPS treated groups compared to the non-stimulated cells. Poly(I:C) was the only TLR ligand, which has induced significant expression of antiviral innate immune response genes from bursal cells. Further in vitro and in vivo studies need to examine the efficacy of these antiviral responses against avian viruses.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Immunology and Immunopathology - Volume 163, Issues 3–4, 15 February 2015, Pages 157–163
نویسندگان
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