کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2461738 1555048 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Type II heat-labile enterotoxins: Structure, function, and immunomodulatory properties
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Type II heat-labile enterotoxins: Structure, function, and immunomodulatory properties
چکیده انگلیسی

The heat-labile enterotoxins (HLTs) of Escherichia coli and Vibrio cholerae are classified into two major types on the basis of genetic, biochemical, and immunological properties. Type I and Type II HLT have been intensively studied for their exceptionally strong adjuvant activities. Despite general structural similarities, these molecules, in intact or derivative (non-toxic) forms, display notable differences in their mode of immunomodulatory action. The molecular basis of these differences has remained largely uncharacterized until recently. This review focuses on the Type II HLTs and their immunomodulatory properties which depend largely on interactions with unique gangliosides and Toll-like receptors that are not utilized by the Type I HLTs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Immunology and Immunopathology - Volume 152, Issues 1–2, 15 March 2013, Pages 68–77
نویسندگان
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