کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2461952 1555061 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enhanced proinflammatory cytokine activity during experimental bluetongue virus-1 infection in Indian native sheep
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Enhanced proinflammatory cytokine activity during experimental bluetongue virus-1 infection in Indian native sheep
چکیده انگلیسی

Bluetongue disease has been causing variable morbidity and mortality in sheep in India and other countries of the world. The experimental infection with Indian BTV-1 strain induced mild to sub-acute infection in native sheep. There were low induction of IL-12, IFN-γ and TNF-α cytokine mRNA expressions determined by real time RT-PCR in draining lymph nodes (DLN), spleen, and PBMCs during the initial stages of infection (8 days post inoculation, DPI) and higher around 15 DPI. The reduced pro-inflammatory cytokine (IFN-γ and TNF-α) responses during the initial stage of infection (8 DPI) was also accompanied by similarly decreased T-cell populations and overt clinical symptoms. Later up regulation of these cytokines and substantial increase in the proportion of CD8+ T-cells occurred with reduction of clinical signs and disappearance of BTV-1 antigen from tissues as determined by immunohistochemistry and RT-PCR. Thus there is definite involvement of pro-inflammatory cytokines and CD8+ T cell activity in disease induced by BTV-1 strain.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Immunology and Immunopathology - Volume 145, Issues 1–2, 15 January 2012, Pages 485–492
نویسندگان
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