کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2462259 1555071 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Adiponectin and IGF-1 are negative acute phase proteins in a dog model of acute endotoxaemia
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Adiponectin and IGF-1 are negative acute phase proteins in a dog model of acute endotoxaemia
چکیده انگلیسی

The objective of this study was to evaluate the influence of an experimentally induced acute inflammation on serum adiponectin and insulin-like growth factor 1 (IGF-1) levels in the dog, and to compare their evolution with other well-established acute phase proteins (APPs) such as C-reactive protein (CRP), and haptoglobin (Hp). Therefore levels of adiponectin, IGF-1 and a profile of APPs were measured in healthy dogs after intravenous administration of E. coli LPS (0.02 mg/kg) and compared with dogs injected with saline solution (0.2 mL/kg). Adiponectin and IGF-1 were both decreased in response to endotoxins in the dog. Significant positive correlations were found between adiponectin and IGF-1 (r = 0.31; p < 0.05). Adiponectin had also a significant negative correlation with CRP (r = −0.39; p < 0.05) and Hp (r = −0.27; p < 0.05), whereas IGF-1 had significant negative correlation with CRP (r = −0.52; p < 0.001).The results obtained in the present study indicate that adiponectin and IGF-1behave as negative acute phase proteins after acute inflammatory stimulus in dogs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Immunology and Immunopathology - Volume 140, Issues 1–2, 15 March 2011, Pages 147–151
نویسندگان
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