کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2462402 1555077 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Differential distribution of WC1+ γδ TCR+ T lymphocyte subsets within lymphoid tissues of the head and respiratory tract and effects of intranasal M. bovis BCG vaccination
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Differential distribution of WC1+ γδ TCR+ T lymphocyte subsets within lymphoid tissues of the head and respiratory tract and effects of intranasal M. bovis BCG vaccination
چکیده انگلیسی

BCG vaccination of neonatal calves induces significant protection against bovine tuberculosis. The enhanced protection observed in neonatal calves may be linked to an enhanced capacity for IFNγ production by innate cells, including WC1+ γδ T cells, which constitute a major population in young cattle. Intranasal BCG vaccination of mice induces high levels of IFNγ in the lungs, which may enhance protection against subsequent challenge with virulent strains of mycobacteria. We used an intranasal BCG vaccination model in calves to study the effect on the distribution of WC1+ γδ T cells expressing two alternate forms of WC1: WC1.1 and WC1.2. These subsets of WC1+ γδ T cells have previously been shown to have a differential capacity for IFNγ secretion. Our results indicate that there is a selective expansion/recruitment of γδ T cells expressing the IFNγ-associated WC1.1 isoform in tissues of the lungs and upper respiratory tract following intranasal BCG vaccination.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Immunology and Immunopathology - Volume 136, Issues 1–2, July 2010, Pages 133–137
نویسندگان
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