کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2463391 1555120 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Astroglial cells in primary culture: A valid model to study Neospora caninum infection in the CNS
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Astroglial cells in primary culture: A valid model to study Neospora caninum infection in the CNS
چکیده انگلیسی

The protozoan Neospora caninum has a veterinary importance because it causes abortion in cattle and neuromuscular alterations in dogs. We infected rat astrocytes, in vitro, with different concentrations of N. caninum. Astrocytes responded to infection by producing the pro-inflammatory cytokine TNF-α and the neurotoxic—free radical NO, 24 and 72 h post-infection. These data suggest that astrocytes, which are essential for brain function, are targets for the parasite and this represents a practical and valid model to study the effects of N. caninum on the CNS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Immunology and Immunopathology - Volume 113, Issues 1–2, 15 September 2006, Pages 243–247
نویسندگان
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