کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2463404 1555116 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interferon-γ expression associated with suppression of bovine leukemia virus at the early phase of infection in sheep
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Interferon-γ expression associated with suppression of bovine leukemia virus at the early phase of infection in sheep
چکیده انگلیسی

Immunological control of bovine leukemia virus (BLV)-infection has been reported as dependent on the expression balance of types 1 and 2 cytokines. In this report, mRNA expression of interferon (IFN)-γ and interleukin (IL)-2 (type 1 cytokines), and of IL-4 and IL-10 (type 2 cytokines) were evaluated in concanavalin A-stimulated peripheral blood mononuclear cells (PBMC) from BLV-infected sheep. Despite the same dose of BLV-infection, the extent of viral propagation was markedly different between eight individual sheep by 12 weeks post infection. The virus did not propagate well in three sheep, which showed augmented mRNA expression of IFN-γ, a strong indicator of cell-mediated immunity, immediately after BLV-infection. Among the other five sheep having more than 2% of BLV-infected cells among PBMC at 12 weeks post infection, four sheep developed B-cell leukemia or lymphoma within 2 years after infection. These observations indicate IFN-γ expression may play an important role in the protective mechanism against BLV propagation at the early phase of the infection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Immunology and Immunopathology - Volume 115, Issues 1–2, 15 January 2007, Pages 17–23
نویسندگان
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