کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2463447 1555121 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expression of tumor necrosis factor-α in IgM+ B-cells from bovine leukemia virus-infected lymphocytotic sheep
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Expression of tumor necrosis factor-α in IgM+ B-cells from bovine leukemia virus-infected lymphocytotic sheep
چکیده انگلیسی

Tumor necrosis factor (TNF)-α is thought to be one of the cytokines that account for bovine leukemia virus (BLV)-induced B-cell lymphoproliferative disorder, however, information on TNF-α expression in B-cells is limited. In this study, the expression of TNF-α in IgM+ B-cells from BLV-infected sheep with or without lymphocytosis was determined. Freshly isolated IgM+ B-cells from three sheep with lymphocytosis constitutively transcribed TNF-α mRNA. Although TNF-α mRNA expression in IgM+ B-cells was transiently up-regulated after cell culture, TNF-α mRNA expression was markedly higher in lymphocytotic sheep when compared to that of non-lymphocytotic sheep or uninfected sheep. Expression of membrane-bound TNF-α on IgM+ B-cells was also augmented in lymphocytotic sheep. TNF-α expression in lymphocytotic sheep may support the proliferation of B-cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Immunology and Immunopathology - Volume 112, Issues 3–4, 15 August 2006, Pages 296–301
نویسندگان
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