کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2464140 1111773 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Broad-spectrum activity of a novel antibiotic peptide against multidrug-resistant veterinary isolates
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Broad-spectrum activity of a novel antibiotic peptide against multidrug-resistant veterinary isolates
چکیده انگلیسی

The emergence of multidrug resistant (MDR) and extensively drug resistant (XDR) bacteria has become a medical and veterinary problem. Antimicrobial peptides (AMPs) show potential to overcome antibiotic resistance and could be used therapeutically. A novel AMP (AMP2041) was developed in silico and its microbiocidal activity against MDR clinical strains isolated from cattle (n = 6), dogs (n = 8), and pigs (n = 20) was evaluated.AMP2041 showed strong antimicrobial activity against all Gram-positive and Gram-negative MDR clinical strains tested. Within 20 min of incubation, there was complete killing of Pseudomonas aeruginosa ATCC 27953 and a 90% reduction of colony count for Escherichia coli ATCC 25922. For Staphylococcus aureus ATCC 25923, a 90% reduction of colony count was observed within 120 min of incubation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Veterinary Journal - Volume 198, Issue 2, November 2013, Pages 534–537
نویسندگان
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