کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2464390 1111793 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Masitinib as a chemosensitizer of canine tumor cell lines: A proof of concept study
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Masitinib as a chemosensitizer of canine tumor cell lines: A proof of concept study
چکیده انگلیسی

Masitinib, a selective tyrosine kinase inhibitor, has previously been shown to enhance the antiproliferative effects of gemcitabine in human pancreatic cancer, demonstrating potential as a chemosensitizer. This exploratory study investigated the ability of masitinib to sensitize various canine cancer cell lines to doxorubicin, vinblastine, and gemcitabine. Masitinib strongly sensitized histiocytic sarcoma cells to vinblastine (>70-fold reduction in IC50 at 5 μM masitinib), as well as osteosarcoma and mammary carcinoma cells to gemcitabine (>70-fold reduction at 5–10 μM). In addition, several cell lines were sensitized to doxorubicin (2–10-fold reduction at 10 μM). These data establish proof-of-concept that masitinib in combination with chemotherapeutic agents can generate synergistic growth inhibition in various canine cancers, possibly through chemosensitization. The findings justify further investigation into those combinations that may potentially yield therapeutic benefit.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Veterinary Journal - Volume 191, Issue 1, January 2012, Pages 131–134
نویسندگان
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