کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2464416 | 1111794 | 2012 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The association between indicators of inflammation and liver variables during the transition period in high-yielding dairy cows: An observational study The association between indicators of inflammation and liver variables during the transition period in high-yielding dairy cows: An observational study](/preview/png/2464416.png)
During the transition period, cows are confronted with infectious and inflammatory challenges leading to an acute phase response (APR) marked by increased hepatic synthesis of positive acute phase reactants (+AP) and a decrease in negative acute phase reactants (−AP). The aim of this study was to quantify the APR in 21 high-yielding dairy cows studied from 9 days before until 42 days after calving, and to assess the association between the APR, disease incidence and indicators of liver function. Repeated blood samples were analyzed for −AP (retinol, albumin, cholesterol), +AP (haptoglobin, caeruloplasmin), paraoxonase, and liver-associated variables (aspartate aminotransferase, γ-glutamyl transferase, bilirubin).All cows displayed postpartum decreases in −AP and paraoxonase, and increases in +AP and liver variables. When retrospectively categorized, cows presenting a stronger −AP decline displayed higher +AP and liver variables, and a higher disease incidence compared to cows with a milder decline. Altogether, typical changes in −AP and +AP identify the transition period as a time of increased inflammatory load. Group differences in liver variables suggest that a more severe APR may be associated with altered liver function. However, no causal relationship can be proven based on this observational dataset, and results should be interpreted cautiously.
Journal: The Veterinary Journal - Volume 192, Issue 2, May 2012, Pages 222–225