کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2465429 1111829 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Perioperative desmopressin prolongs survival in surgically treated bitches with mammary gland tumours: A pilot study
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Perioperative desmopressin prolongs survival in surgically treated bitches with mammary gland tumours: A pilot study
چکیده انگلیسی

Desmopressin (1-deamino-8-d-arginine vasopressin, also known as DDAVP) is a safe haemostatic compound capable of inhibiting lymph node and lung metastasis in a mouse model of mammary tumour manipulation and surgical excision. The aim of this study was to test the efficacy and safety of perioperative DDAVP (1 μg/kg) in surgically treated bitches with mammary gland tumours (MGT). Twenty-one, otherwise healthy, intact bitches, with malignant MGT stage III or IV were randomly allocated to DDAVP (n = 11) or placebo (n = 10) groups. En bloc mastectomy of the affected gland/s was performed. DDAVP had a significant beneficial effect on disease-free period (P < 0.01) and overall survival time (P < 0.05). No side effects were seen in any of the cases. Whatever the mechanism of action, it seems that DDAVP may have a novel use in cancer surgery to minimise spread or survival of residual malignant cells. Additional, large scale controlled trials are required to fully evaluate this adjuvant pharmacological protocol.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Veterinary Journal - Volume 178, Issue 1, October 2008, Pages 103–108
نویسندگان
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