کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2465577 1111834 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of etamsylate on equine platelets: In vitro and in vivo studies
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Effects of etamsylate on equine platelets: In vitro and in vivo studies
چکیده انگلیسی

The aim of this study was to investigate whether etamsylate produces equine platelet activation. In vitro and in vivo studies were designed in which seven and eight adult healthy horses were included, respectively. In the in vitro study, citrated blood was incubated with different concentrations of etamsylate, and P-selectin expression and annexin V binding were determined by flow cytometry. In the in vivo study, blood was collected before and 1 and 2 h after IV administration of etamsylate, and P-selectin expression was evaluated.In the in vitro study, a significant increase in P-selectin expression, leukocyte–platelet aggregate formation and annexin V binding were observed. In the in vivo study, a marked increase in P-selectin expression and heterotypic aggregate formation was seen in two and five horses, respectively, although no significant differences were detected when analyzing results from all the animals together. The results of the in vitro study indicate that etamsylate produces a pre-activation state in equine platelets, but this fact could be confirmed by the in vivo study.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Veterinary Journal - Volume 174, Issue 2, September 2007, Pages 325–329
نویسندگان
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