کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2465638 | 1111835 | 2007 | 6 صفحه PDF | دانلود رایگان |

This study was designed to evaluate the effectiveness of neuromuscular blockade with rocuronium bromide (rocuronium) in eighty dogs anaesthetised for a variety of surgical procedures. Rocuronium 0.3 or 0.6 mg/kg (G03 and G06) was administered intravenously (IV) and neuromuscular function was monitored with an acceleromyograph. Lag time (LT) was >1 min in both groups. Onset time (OT) was 2 ± 0.9 and 1.1 ± 0.6 min in the groups given 0.3 and 0.6 mg/kg, respectively. There was a significantly longer time of action with 0.6 mg/kg in contrast to 0.3 mg/kg rocuronium. Time of no response (TonR) was 9.1 ± 4.9–16.9 ± 6.1 min in the groups given 0.3 and 0.6 mg/kg, respectively. The time from the end of injection until 25% recovery of the first twitch from the baseline value (T125) was 13.8 ± 5.5 and 22.3 ± 6.7 min in the groups given 0.3 and 0.6 mg/kg, respectively. T125–75 was similar in both groups. Total recovery to baseline values was achieved in 23.8 ± 6.6 and 31.9 ± 6.5 min in the groups given 0.3 and 0.6 mg/kg, respectively (P < 0.05). Premedication, maintenance agent, body position and stimulation site had no significant influence on the pharmacodynamic parameters in both groups. It was concluded that rocuronium is an effective non-depolarising muscle relaxant in the dog under clinical conditions.
Journal: The Veterinary Journal - Volume 173, Issue 2, March 2007, Pages 422–427