کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2465906 1111844 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pharmacokinetics and milk penetration of moxifloxacin after intravenous and subcutaneous administration to lactating goats
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Pharmacokinetics and milk penetration of moxifloxacin after intravenous and subcutaneous administration to lactating goats
چکیده انگلیسی

The pharmacokinetics of moxifloxacin was studied following intravenous (IV) and subcutaneous (SC) administration of 5 mg/kg to healthy lactating goats (n = 6). Moxifloxacin concentrations were determined by high performance liquid chromatography assay with fluorescence detection. The moxifloxacin plasma concentration versus time data after IV administration could best be described by a two compartment open model. The disposition of SC administered moxifloxacin was best described by a one-compartment model. The plasma moxifloxacin clearance (Cl) for the IV route was 0.43 ± 0.02 L/kg (mean ± SE). The steady-state volume of distribution (Vss) was 0.79 ± 0.08 L/kg. The terminal half-life (t1/2λz) was 1.94 ± 0.41 and 2.98 ± 0.48 h after IV and SC administration, respectively. The absolute bioavailability was 96.87 ± 10.27% after SC administration. Moxifloxacin penetration from blood to milk was quick for both routes of administration and the high AUCmilk/AUCplasma and Cmax-milk/Cmax-plasma ratios reached indicated a wide penetration of moxifloxacin into the milk. From these data, it appears that a 5 mg/kg SC dose of moxifloxacin would be effective in lactating goats against bacterial isolates with MIC ⩽ 0.20 μg/mL in plasma and MIC ⩽ 0.40 μg/mL in milk.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Veterinary Journal - Volume 172, Issue 2, September 2006, Pages 302–307
نویسندگان
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