کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2466329 1111858 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Engagement of integrins as a cellular route of invasion by bacterial pathogens
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Engagement of integrins as a cellular route of invasion by bacterial pathogens
چکیده انگلیسی

Integrins are heterodimeric receptors that mediate important cell functions, including cell adhesion, migration and tissue organisation. These transmembrane receptors regulate the direct association of cells with each other and with extracellular matrix proteins. However, by binding their ligands, integrins provide a transmembrane link for the bidirectional transmission of mechanical forces and biochemical signals across the plasma membrane. Interestingly, several of this family of receptors are exploited by pathogens to establish contact with the host cells. Hence, microbes subvert normal eukaryotic cell processes to create a specialised niche which allows their survival. This review highlights the fundamental role of integrins in bacterial pathogenesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Veterinary Journal - Volume 173, Issue 3, May 2007, Pages 482–491
نویسندگان
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