کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2482927 | 1113884 | 2011 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Free Radicals Cardiovascular Diseases: An Update
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
پزشکی مولکولی
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چکیده انگلیسی
In recent years, a multitude of studies provide comprehenisve evidence that increased production of reactive oxygen species (ROS) are involved in the development and progression of cardiovascular diseases. The ROS are common by- products of many oxidative biochemical and physiological processes. They can be released by mitochondrial respiration, NADH/NADPH oxidase, xanthine oxido-reductase or the uncoupling of nitric oxide synthase (NOS) in vascular cells. ROS mediate various signaling pathways that underlie cardiovascular pathophysiology. In a number of cardiovascular disease conditions, the delicate equilibrium between free-radical generation and antioxidant defense is altered in favor of the former, thus leading to redox imbalance i.e. escalating oxidative stress and increased tissue injury. This review focuses on the updated evidences concerning involvement of ROS in cardiovascular diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radicals and Antioxidants - Volume 1, Issue 1, JanuaryâMarch 2011, Pages 17-22
Journal: Free Radicals and Antioxidants - Volume 1, Issue 1, JanuaryâMarch 2011, Pages 17-22
نویسندگان
Sanjib Bhattacharya, K.K. Mueen Ahmed, Subhankar Chakraborty,