کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2488908 1556553 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Possible role of antioxidants and nitric oxide inhibitors against carbon monoxide poisoning: Having a clear conscience because of their potential benefits
ترجمه فارسی عنوان
نقش احتمالی آنتی اکسیدان ها و مهارکننده های اکسید نیتریک در برابر مسمومیت کربن مونوکسید: داشتن وجدان روشن به علت مزایای بالقوه آن
کلمات کلیدی
مسمومیت با مونوکسید کربن؛ فقدان اکسیژن، آسیب دیدگی؛ گونه های اکسیژن واکنش پذیر؛ اکسید نیتریک؛ آنتیاکسیدان درمانی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
چکیده انگلیسی

Carbon monoxide poisoning is one of the important emergency situations manifested by primarily acute and chronic anoxic central nervous system (CNS) injuries and other organ damages. Current descriptions and therapeutic approaches have been focused on the anoxic pathophysiology. However, this point of view incompletely explains some of the outcomes and needs to be investigated extensively. Considering this, we propose that reactive oxygen species (ROS) including especially nitric oxide (NO) are likely to be a key concept to understand the emergency related to CO poisoning and to discover new therapeutic modalities in CO toxicity. If we consider the hypothesis that ROS is involved greatly in acute and chronic toxic effects of CO on CNS and some other vital organs such as heart, it follows that the antioxidant and anti-NO therapies might give the clinicians more opportunities to prevent deep CNS injury. In support of this, we review the subject in essence and summarize clinical and experimental studies that support a key role of ROS in the explanation of pathophysiology of CO toxicity as well as new treatment modalities after CO poisoning.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Hypotheses - Volume 92, July 2016, Pages 3–6
نویسندگان
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