کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2495568 | 1116069 | 2012 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development and validation of HPTLC method for the determination of mycophenolate mofetil in bulk and pharmaceutical formulation
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
پزشکی مولکولی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Aim: Described in this manuscript is the first ever reported, new, simple, high- performance thin-layer chromatographic method for the determination of mycophenolate mofetil in bulk and tablet dosage form. Materials and Methods: The drug was separated on aluminum plates precoated with silica gel 60Â F254 with toluene, acetone, and methanol in the ratio of 6:2:2 (v/v/v) as the mobile phase. Quantitative analysis was performed by densitometric scanning at 254Â nm. Results: The method was validated for linearity, accuracy, precision, and robustness. The calibration plot was linear in the range of 100-500Â ng band-Â 1 for mycophenolate mofetil. The method was successfully applied to the analysis of the drug in a pharmaceutical dosage form.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmaceutical Methods - Volume 3, Issue 2, JulyâDecember 2012, Pages 90-93
Journal: Pharmaceutical Methods - Volume 3, Issue 2, JulyâDecember 2012, Pages 90-93
نویسندگان
S. Kathirvel, K. Rajendra Prasad, K. Madhu Babu,