کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2495592 1116071 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A simple and precise method for quantitative analysis of lumefantrine by planar chromatography
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی پزشکی مولکولی
پیش نمایش صفحه اول مقاله
A simple and precise method for quantitative analysis of lumefantrine by planar chromatography
چکیده انگلیسی
A simple, precise and sensitive high performance thin layer chromatographic (HPTLC) method has been developed and validated for drug of choice Lumefantrine in treatment of malaria (P.falciparum). Silica gel 60 F254 HPTLC precoated plates were used for quantitative analytical purpose. Methanol: water 9.5 + 0.5 (v/v) was used as the solvent system. Densitometric scanning was carried out with deuterium lamp set at detection wavelength of 266 nm. The response to lumefantrine concentration was linear in the concentration range of 1.25-12.50 μg/ml. The suitability of the method developed and validated was in accordance with the requirements of the ICH guidelines (Q2B). Thus the validated method can be further applied to quantitative analysis of lumefantrine in commercial pharmaceutical dosage form. The proposed method is simple, sensitive, precise and accurate, confirming its pharmaceutical application in routine quality control analysis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmaceutical Methods - Volume 1, Issue 1, October–December 2010, Pages 44-48
نویسندگان
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