کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2495592 | 1116071 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A simple and precise method for quantitative analysis of lumefantrine by planar chromatography
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
پزشکی مولکولی
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چکیده انگلیسی
A simple, precise and sensitive high performance thin layer chromatographic (HPTLC) method has been developed and validated for drug of choice Lumefantrine in treatment of malaria (P.falciparum). Silica gel 60 F254 HPTLC precoated plates were used for quantitative analytical purpose. Methanol: water 9.5 + 0.5 (v/v) was used as the solvent system. Densitometric scanning was carried out with deuterium lamp set at detection wavelength of 266 nm. The response to lumefantrine concentration was linear in the concentration range of 1.25-12.50 μg/ml. The suitability of the method developed and validated was in accordance with the requirements of the ICH guidelines (Q2B). Thus the validated method can be further applied to quantitative analysis of lumefantrine in commercial pharmaceutical dosage form. The proposed method is simple, sensitive, precise and accurate, confirming its pharmaceutical application in routine quality control analysis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmaceutical Methods - Volume 1, Issue 1, OctoberâDecember 2010, Pages 44-48
Journal: Pharmaceutical Methods - Volume 1, Issue 1, OctoberâDecember 2010, Pages 44-48
نویسندگان
Purnima Hamrapurkar, Mitesh Phale, Sandeep Pawar, Priti Patil, Mittal Gandhi,