کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2495613 1116073 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A validated high-performance thin layer chromatography method for estimation of lornoxicam and paracetamol in their combined tablet dosage form
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی پزشکی مولکولی
پیش نمایش صفحه اول مقاله
A validated high-performance thin layer chromatography method for estimation of lornoxicam and paracetamol in their combined tablet dosage form
چکیده انگلیسی
Introduction: Lornoxicam (LORN) a nonsteroidal antiinflammatory drug of oxicam class is marketed in combination with Paracetamol, a common analgesic for acute inflammatory disease of joints. Materials and Methods: LORN and Paracetamol (PCM) were estimated at 280 nm by densitometry using silica gel 60 F 254 as stationary phase and a premix of toluene: chloroform: methanol: formic acid (3:5:1.5:0.2 v/v/v/v) as mobile phase. The method was found linear in a range of 160-560 nanograms/spot for LORN and 10 000-35 000 nanograms/spot for PCM with a correlation coefficient > 0.99 for both. Result: PCM and LORN were well resolved with Rf 0.57 ± 0.02 and 0.75 ± 0.02, respectively. Conclusions: The developed high-performance thin layer chromatography method was found to be simple, specific, precise, and reproducible and can be used for the routine estimation of LORN and PCM in the combined tablet dosage form, available in market.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmaceutical Methods - Volume 2, Issue 2, April–June 2011, Pages 83-87
نویسندگان
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