کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2495615 1116073 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sensitive and accurate estimation of losartan potassium formulation by high-performance thin-layer chromatography
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی پزشکی مولکولی
پیش نمایش صفحه اول مقاله
Sensitive and accurate estimation of losartan potassium formulation by high-performance thin-layer chromatography
چکیده انگلیسی
Aim and Objectives: To develop a simple sensitive cost-efiective and reproducible UVspectrophotometric method and validate for the estimation of disodium edetate in topical gel formulations. Materials and Methods: Solution of disodium edetate reacts with ferric chloride to form complex in 0.1 N HC1 giving λmax at 270 nm. Beer's law was obeyed in the concentration range of 5-50 μg/mL (r2 = 0.9997). Results: The limit of detection and limit of quantitation were found to be 1.190 and 3.608 μg/mL respectively. The results show that the procedure is accurate precise and reproducible (relative standard deviation < 1%) while being simple and less time consuming. Conclusions: The study concluded that the UV-spectrophotometric method could be used for the quantification of disodium edetate in pure form as well as in pharmaceutical formulations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmaceutical Methods - Volume 2, Issue 2, April–June 2011, Pages 95-98
نویسندگان
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