کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2495881 1116092 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vitro Anthelmintic Activity of Stem Extracts of Piper betle Linn Against Pheritima Posthuma
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی پزشکی مولکولی
پیش نمایش صفحه اول مقاله
In vitro Anthelmintic Activity of Stem Extracts of Piper betle Linn Against Pheritima Posthuma
چکیده انگلیسی
The mode of action of Albendazole is to cause paralysis of worms and to expel them in the feaces. Albendazole causes degenerative alterations in the intestinal cells of the worm. Degenerative changes in organs like endoplasmic reticulum, the mitochondria results in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminthes. Due to diminished energy production, the parasite is immobilized and eventually dies. The ethanolic extract of stems of Piper betle Linn not only demonstrated anthelmintic property but they also caused death of the worms when compared with marketed standard preparation i.e. Albendazole (40mg/ml) and different concentrations of aqueous extract. It is concluded that stems of Piper betle Linn is potent anthelmintic. Since this is the preliminary work, separation of chemical constituents which are responsible for the activity may be done in the future.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacognosy Journal - Volume 4, Issue 29, May–June 2012, Pages 61-65
نویسندگان
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