کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2577588 1129951 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vitro and in vivo evaluation of efficacy and safety of photoprotective formulations containing antioxidant extracts
ترجمه فارسی عنوان
ارزیابی اثربخشی و ایمنی فرمولاسیون های محافظتی فاقد عصاره های آنتی اکسیدان در شرایط آزمایشگاهی و داخل بدن
کلمات کلیدی
عصاره برگ؛ فرمول بندی لوازم آرایشی و بهداشتی؛ عکسبرداری؛ اثربخشی و ایمنی؛ روش های ارزیابی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
چکیده انگلیسی

Chronic exposure to solar radiation could contribute to premature skin aging and skin cancer. Skin presents its own antioxidant defense, however when defenses are out of balance, reactive oxygen species could damage biological structures. In the present work, an oil-in-water photoprotective emulsion was developed and Bauhinia microstachya var. massambabensis Vaz, Fabaceae, extracts at 1% (obtained by extraction with different solvents) were added to this emulsion. In vitro and in vivo efficacy and safety of the formulations were evaluated. Spectrophotometric methods and in vivo Colipa test were performed to evaluated efficacy of the formulations, through sun protection factor (SPF) determination and UVA protection factor assessment. To the in vitro safety assessment HET-CAM, CAM-TBS and Red Blood Cell tests were performed. Results showed that both extracts contributed to a higher in vivo photoprotection (SPF 18) when compared to the formulation without extract (SPF 13), this result could be attributed to the antioxidant activity of the plant extracts that act by capturing reactive oxygen species. Concerning safety, all formulations were considered non-irritant according to in vitro tests. Formulations containing extracts could be considered efficient and safe for cosmetic use since they presented higher sun protection factor and passed the toxicity tests.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revista Brasileira de Farmacognosia - Volume 26, Issue 2, March–April 2016, Pages 251–258
نویسندگان
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