کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2680307 1142340 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association between the outcome of traumatic brain injury patients and cerebrovascular autoregulation, cerebral perfusion pressure, age, and injury grades
ترجمه فارسی عنوان
ارتباط میان نتیجه بیماران پس از سانحه آسیب های مغزی و تنظیمی عروق مغزی، فشار پرفیوژن مغزی، سن و درجات آسیب
کلمات کلیدی
نتیجه؛ آسیب تروماتیک مغز؛ نظارت تنظیمی عروق مغزی؛ فشار پرفیوژن مغزی بهینه
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
چکیده انگلیسی

Background and objectiveThe aim of this study was to explore the association of cerebrovascular autoregulation (CA) and optimal cerebral perfusion pressure (CPP) managing conditions with the outcome of traumatic brain injury (TBI) patients including additional information about the patients’ age and grade of diffuse axonal injury (DAI).Materials and methodsThe CA monitoring of 28 TBI patients was performed by using ICM+ software (Cambridge, UK). The CA status estimating pressure reactivity indexes (PRx) and CPP data were processed in order to obtain information on the patient-specific treatment conditions by calculating the optimal CPP.ResultsThere was a negative correlation between the Glasgow outcome scale (GOS) score and PRx (r = −0.448 at hospital discharge and r = −0.402 after 6 months). The estimated threshold value PRx of >0.24 was associated with mortality. The correlation coefficients between the GOS score and the difference CPP-optimal CPP were 0.549 at hospital discharge and 0.484 after 6 months. The threshold value of CPP declination from ΔCPPopt per −6 mmHg was associated with mortality. Poorer outcome was predicted for elderly TBI patients (aged >47 years) and patients having a DAI grade of 3.ConclusionsThe association of the GOS score with CPP, CA impairment conditions, age and diffuse axonal injury (DAI) grade showed that the outcomes of TBI patients were associated with patient-specific CPP management and better outcomes were obtained for younger patients, for patients having lower DAI grade and for patients whose CPP was kept within the range from the optimal CPP to the optimal CPP + 10 mmHg.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medicina - Volume 52, Issue 1, 2016, Pages 46–53
نویسندگان
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