کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2777550 1568027 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Altered maternal proportions of long chain polyunsaturated fatty acids and their transport leads to disturbed fetal stores in preeclampsia
ترجمه فارسی عنوان
نسبت تغذیه مادران از اسیدهای چرب غیر اشباع زنجیره ای طولانی و انتقال آنها منجر به اختلال در فروشگاه های جنین در پره اکلامپسی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
چکیده انگلیسی

Our previous cross-sectional studies have shown altered proportions of long chain polyunsaturated fatty acids (LCPUFA) in preeclampsia (PE) at the end of pregnancy when the pathology has already progressed. The present longitudinal study for the first time reports fatty acid proportions from 16th week of gestation till delivery and placental transport in PE. This is a hospital based study where women were recruited in early pregnancy. Maternal blood was collected at 3 time points i.e. T1=16–20th week, T2=26–30th week and T3=at delivery. Cord blood and placenta were collected at delivery. This study reports data on 140 normotensive control (NC) and 54 PE women. In PE we report lower proportions of DHA in maternal plasma at T1, cord plasma and placenta (p<0.05 for all). The mRNA levels of placental ∆5 desaturase, fatty acid transport proteins -1, -4, were lower (p<0.05 for all) in PE. There was also a positive association between cord and maternal plasma DHA and total omega-3 fatty acids at T1. This study demonstrates that women with PE have lower fatty acids stores at 16–20th week of gestation and lower placental synthesis and transport. It is likely that supplementation of omega-3 fatty acids during the 16–20th week of gestation may help in improving fatty acid status in infants born to mothers with PE.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Volume 91, Issues 1–2, July–August 2014, Pages 21–30
نویسندگان
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