کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2778267 1152800 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dietary eicosapentaenoic acid modulates CTLA-4 expression in murine CD4+ T-cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
Dietary eicosapentaenoic acid modulates CTLA-4 expression in murine CD4+ T-cells
چکیده انگلیسی

We have demonstrated that downregulation of proliferation by CD4+ T-cells in mice fed n-3 PUFA diets is dependent on the involvement of CD28. Therefore, we hypothesized that the balance of co-stimulatory and downregulatory properties of CD28 and CTLA-4, respectively, would be altered by diet. Mice were fed a control corn oil (CO)-enriched diet devoid of n-3 PUFA, or diets enriched with either docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA) for 14 d. The proliferation of splenic CD4+ T-cells was suppressed by DHA and EPA following stimulation with anti-CD3 and anti-CD28. Surprisingly, the number of surface CD28 molecules was not reduced in activated CD4+ T-cells from either group of n-3 PUFA-fed mice. However, in mice fed EPA, CTLA-4 protein levels were enhanced significantly 72 h post-activation (P<0.01). Therefore, we conclude that dietary EPA may suppress CD4+ T-cell activation by enhancing the downregulatory co-receptor CTLA-4, while not altering the levels of CD28.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids - Volume 74, Issue 1, January 2006, Pages 29–37
نویسندگان
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