کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2778321 1568049 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An n-3 fatty acid deficient diet affects mouse spatial learning in the Barnes circular maze
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
An n-3 fatty acid deficient diet affects mouse spatial learning in the Barnes circular maze
چکیده انگلیسی

Deficiency in n-3 fatty acids has been accomplished through the use of an artificial rearing method in which ICR mouse pups were hand fed a deficient diet starting from the 2nd day of life. There was a 51% loss of total brain DHA in mice with an n-3 fatty acid-deficient diet relative to those with a diet sufficient in n-3 fatty acids. n-3 fatty acid adequate and deficient mice did not differ in terms of locomotor activity in the open field test or in anxiety-related behavior in the elevated plus maze. The n-3 fatty acid-deficient mice demonstrated impaired learning in the reference-memory version of the Barnes circular maze as they spent more time and made more errors in search of an escape tunnel. No difference in performance between all dietary groups in the cued and working memory version of the Barnes maze was observed. This indicated that motivational, motor and sensory factors did not contribute to the reference memory impairment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids - Volume 77, Issues 5–6, November–December 2007, Pages 269–277
نویسندگان
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