کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2788377 | 1568565 | 2016 | 8 صفحه PDF | دانلود رایگان |
• The role of glycocalyx in pathogenesis of preeclampsia is the subject to discuss.
• Hypoglycosylation of syncytiotrophoblast may be one of the mechanisms responsible for immunological tolerance.
• Most prominent alterations of the glycocalyx are marked in severe preeclampsia.
• Sialic acids play prime role as masking antigens that provide immunological tolerance.
IntroductionGlycans expressed in the fetal-maternal interface were shown to exert immunomodulating effects and to mediate interactions between the cells. The aim of this study was to investigate alterations in the structure of carbohydrate chains of glycocalyx in placental tissue in pregnancies complicated with preeclampsia (PE).MethodsA histochemical analysis of placental tissues was performed with a panel of biotinylated lectins. We analyzed placental tissues in women who had severe or moderate PE and compared them to placentas from women with normal pregnancies.ResultsThere was decreased content of terminal residues of α(2,6)-linked sialic acid (as stained by SNA lectin) in the carbohydrate chains of glycocalyx of the endothelium of placental terminal villi in patients with moderate preeclampsia. The composition of the glycocalyx of syncytiotrophoblast in patients of this group did not differ from the control group. Amount of the glycans with terminal β-Gal- (ECL) and α-mannosyl residues (ConA) in the syncytiotrophoblast and capillary endothelium of the placenta was significantly higher in the group with severe PE compared to the control group. The increased content of sialoglycans with α(2,6)-linked sialic acids residues were discovered in the syncytium, and the decreased content of α(2,3)-linked sialic acids residues – in the endothelium of terminal villi in preeclampsia.DiscussionThe most prominent alteration of the glycocalyx composition was found in the placentas of women with severe preeclampsia. It is likely that the modified glycome of syncytiotrophoblast and capillary endothelium may play an important role in pathogenesis of preeclampsia.
Journal: Placenta - Volume 43, July 2016, Pages 69–76