کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2788648 1154442 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The defect of both angiogenesis and lymphangiogenesis is involved in preeclampsia
ترجمه فارسی عنوان
نقص هر دو آنژیوژنز و لنفانژیوژنز در پره اکلامپسی دخیل است
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
چکیده انگلیسی


• There was lymphangiogenesis in decidua instead of placenta.
• Both the impaired angiogenesis and lymphangiogenesis were associated with preeclampsia.
• The more impaired angiogenesis and lymphangiogenesis correlated with decidual vasculopathy.

IntroductionPre-eclampsia (PE) is characterized by failed remodeling of maternal vessels perfusing the placenta. Blood vessels and lymphatic system are involved in vessel remodeling and flow homeostasis in the uterus during pregnancy. This study aims to investigate the involvement of angiogenesis and lymphangiogenesis in PE.MethodsPlacental and decidual tissues were obtained from pregnancies with PE (n = 90), including PE cases with decidual vasculopathy (DV) (n = 52) and without DV (n = 38), and healthy pregnancies (control, n = 20). The clinical characteristics of these groups were analyzed. The expression levels of VEGF1, CD34, PROX-1, VEGFR3, and CD31 in the placenta and decidua were detected through immunohistochemistry, reverse-transcription polymerase chain reaction, and Western blot.ResultsThe lymphangiogenic markers PROX-1 and VEGFR3 were negatively expressed in the placenta but positively expressed in the decidua. The expression levels of the angiogenic markers VEGF1 and CD34 and the panendothelial marker CD31 were significantly lower in the placenta and decidua of the PE group than in those of the control group. The expression levels of VEGF1, CD34, and CD31 were significantly lower in the placenta and decidua with DV than in those without DV. Furthermore, the expression trends of PROX-1 and VEGFR3 was similar to those of VEGF1, CD34, and CD31 among the groups.ConclusionsLymphangiogenesis occurred in the decidua but not in the placenta. Impaired angiogenesis and lymphangiogenesis were associated with PE, particularly in the presence of DV.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Placenta - Volume 36, Issue 3, March 2015, Pages 279–286
نویسندگان
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