کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2788671 | 1154443 | 2014 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Surprising prenatal toxicity of epidermal lipoxygenase-3 Surprising prenatal toxicity of epidermal lipoxygenase-3](/preview/png/2788671.png)
• Epidermal lipoxygenase-3 may induce fetal growth restriction and intrauterine death.
• We found a lack of glycogen trophoblasts and altered gene expression in the placenta.
• Epidermal lipoxygenase-3 metabolites may have an impact on placental development.
Metabolites of the epidermal lipoxygenase-3 (eLOX-3) are involved in various metabolic pathways. Most unexpectedly, intra-amniotic delivery of eLOX-3 to mice at gestational day 14.5, both via an adenoviral vector and as recombinant protein, resulted in fetal growth restriction and intrauterine death. Periodic acid-Schiff staining and RT-PCR analysis of placentae from fetuses exposed to eLOX-3 indicated a lack of glycogen trophoblasts in the junctional zone. Placenta-specific gene expression was altered. Thus, the observed prenatal toxicity of eLOX-3 could be due to a strong effect on placental development.
Journal: Placenta - Volume 35, Issue 9, September 2014, Pages 776–779