کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2788671 1154443 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Surprising prenatal toxicity of epidermal lipoxygenase-3
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Surprising prenatal toxicity of epidermal lipoxygenase-3
چکیده انگلیسی


• Epidermal lipoxygenase-3 may induce fetal growth restriction and intrauterine death.
• We found a lack of glycogen trophoblasts and altered gene expression in the placenta.
• Epidermal lipoxygenase-3 metabolites may have an impact on placental development.

Metabolites of the epidermal lipoxygenase-3 (eLOX-3) are involved in various metabolic pathways. Most unexpectedly, intra-amniotic delivery of eLOX-3 to mice at gestational day 14.5, both via an adenoviral vector and as recombinant protein, resulted in fetal growth restriction and intrauterine death. Periodic acid-Schiff staining and RT-PCR analysis of placentae from fetuses exposed to eLOX-3 indicated a lack of glycogen trophoblasts in the junctional zone. Placenta-specific gene expression was altered. Thus, the observed prenatal toxicity of eLOX-3 could be due to a strong effect on placental development.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Placenta - Volume 35, Issue 9, September 2014, Pages 776–779
نویسندگان
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