کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2788823 1154451 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Functional immunocytochemistry of Tragulus placenta: Implications for ruminant evolution
ترجمه فارسی عنوان
ایمونوسیتوشیمی عملکردی جفت تراگولوس: پیامدهای تکامل گناهان
کلمات کلیدی
قرار دادن مقایسه، تکامل طاقت فرسا، ایمونوسیتوشیمی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
چکیده انگلیسی

Introduction and methodsTragulus, the mouse deer, is considered the most primitive ruminant, with a diffuse placenta grossly quite unlike the cotyledonary type of the other ruminants. This immunocytochemical investigation of placental transporters was designed to elucidate possible mechanisms of evolution to the cotyledonary form.Results and discussionTragulus expresses several of the major transport systems characteristic of the ruminants: the trophoblast binucleate cell (BNC) dynamics, the requirement for two isoforms, GT1 and GT3, for glucose transport, the provision of Aquaporin 3 for water control, and uterine milk and histiotrophic secretion from uterine glands. However whereas the expression of the 9kD Calcium Binding Protein (9CBP) for calcium transport in ruminants is restricted to the intercotyledonary trophoblast with its areolae, Tragulus, having no intercotyledonary area, expresses 9CBP throughout the villus trophoblast. There is some localised development of areolar-like structures in the mid term Tragulus but it is insignificant at term. The strong expression of Glucose Transporter 1 (GT1) in the BNC granules is unique to Tragulus.ConclusionTragulus relies on essentially similar transport and BNC dynamics as the other ruminants. Thus the evolutionary pressures driving the development of the cotyledonary placenta probably lie in the increase in body size and the consequent need for a larger placental area to ensure sufficient glucose for the fetus. The delivery in Tragulus of GT1 to the maternal facing side may be this species unique solution to maintain the glucose supply.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Placenta - Volume 35, Issue 5, May 2014, Pages 305–310
نویسندگان
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