کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2788988 1154462 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transfer of gangliosides across the human placenta
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Transfer of gangliosides across the human placenta
چکیده انگلیسی

ObjectivesGangliosides are structural and functional glycosphingolipids, considered to have important roles in neuronal development in fetal and neonatal development and in memory formation. In this report, we have investigated the ability of bovine milk-derived gangliosides GM3 and GD3 to cross the human placenta.Study designWe have employed the ex-vivo model of dually-perfused isolated human placental lobules.ResultsThere was significant uptake of both GD3 and GM3 from the maternal perfusate. There was significant increase of GM3 in the fetal side and a non-statistically significant trend for GD3 to increase on the fetal side.ConclusionsHence an apparent preference for GM3 release into fetal circulation. We suggest that gangliosides consumed by the mother enter her circulation, can be transferred across the placenta and may be available to the developing fetus for building neural connections.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Placenta - Volume 33, Issue 4, April 2012, Pages 312–316
نویسندگان
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