کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2789229 1154484 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dysregulated Complement Activation as a Common Pathway of Injury in Preeclampsia and Other Pregnancy Complications
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Dysregulated Complement Activation as a Common Pathway of Injury in Preeclampsia and Other Pregnancy Complications
چکیده انگلیسی

The complement system protects the host against invading organisms, initiates inflammation and dispose of immune complexes and the products of inflammatory injury. The complement system provides an important link between the innate and adaptive immune systems. Experimental observations suggest that increased complement activation causes and/or perpetuates inflammation during pregnancy. Recent studies suggest a link between complement activation and preeclampsia. Excessive activation or insufficient regulation of complement recruits leukocytes and unleashes potent inflammatory and anti-angiogenic mediators associated with placental insufficiency and maternal endothelial dysfunction characteristic of preeclampsia. We review the animal and human studies that link complement activation and pathogenic events in preeclampsia, present evidence that activation of the complement system is associated with the development of preeclampsia and provides new targets to prevent its complications.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Placenta - Volume 31, Issue 7, July 2010, Pages 561–567
نویسندگان
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