کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2789499 1154510 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Time-Course Analyses Addressing the Acquisition of DBA Lectin Reactivity in Mouse Lymphoid Organs and Uterus During the First Week of Pregnancy
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Time-Course Analyses Addressing the Acquisition of DBA Lectin Reactivity in Mouse Lymphoid Organs and Uterus During the First Week of Pregnancy
چکیده انگلیسی

Terminal differentiation of uterine natural killer (uNK) cells is induced in humans and mice at the time of endometrial decidualization. In mice, commitment to this lineage is first recognized at gestation day (gd)5.5 when small, non-granulated lymphocytes in the mesometrial decidua basalis become histochemically reactive with the lectin Dolichlos biflorus agglutinin (DBA). Transplantation experiments in mice have shown that the self-renewing progenitors of uNK cells are present in peripheral rather than uterine tissues. While lymphoid tissues of virgin mice lack DBA lectin reactive putative uNK cell precursors or progenitors, peripheral organs have not been systematically examined in female mice during early pregnancy while the uNK cell population is becoming established. Here we report such a study in gd0.5–7.5 random bred mice. Only mesenteric lymph nodes showed a transient gain in DBA lectin reactive lymphocytes between gd0.5 and 4.5. These cells had cytoplasmic but almost no surface DBA lectin reactivity. This study indicates that the decidual environment is unique and locally promotes DBA lectin surface expression in terminally differentiating uNK cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Placenta - Volume 29, Issue 12, December 2008, Pages 1009–1015
نویسندگان
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