کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2789658 1154519 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fetal–Placental Hypoxia Does Not Result from Failure of Spiral Arterial Modification in Mice
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Fetal–Placental Hypoxia Does Not Result from Failure of Spiral Arterial Modification in Mice
چکیده انگلیسی

ObjectivesTo determine if fetal–placental hypoxia is a primary outcome of defective spiral artery remodeling.Study designPregnancies in Rag2−/−Il2rg−/− double knock-out mice, which fail to undergo normal physiological spiral arterial remodeling, were compared to syngeneic BALB/c control pregnancies. Mice at gestation day (gd)6, 8, 10, 12 and 18 were infused with Hypoxyprobe™-1 before euthanasia to enable detection of cellular hypoxia by immunohistochemistry.ResultsIn implantation sites of both phenotypes, trophoblast cells were reactive to Hypoxyprobe™-1. No major differences were observed between the phenotypes in decidua or placenta at any gd or in gd18 fetal brain, lung, heart, liver or intestine or in maternal heart, brain, liver or spleen. Maternal kidneys from BALB/c were significantly hypoxic to Rag2−/−Il2rg−/− kidneys.ConclusionsIn mice, lack of pregnancy-associated spiral artery remodeling does not impair oxygen delivery to the conceptus, challenging the concept that deficient spiral arterial remodeling leads to fetal hypoxia in human gestational complications such as preeclampsia and fetal growth restriction. The isolated hypoxic response of normal kidney has revealed that renal lymphocytes may have unique, tissue-specific regulatory actions on vasoconstriction that are pregnancy independent.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Placenta - Volume 31, Issue 8, August 2010, Pages 731–737
نویسندگان
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