کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2789801 1568576 2007 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
PPARs and the Placenta
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
PPARs and the Placenta
چکیده انگلیسی

The discovery of the peroxisome proliferator-activated receptors (PPARs) in 1990s provided new insights in understanding the mechanisms involved in the control of energy homeostasis and in cell differentiation, proliferation, apoptosis and the inflammatory process. The PPARs became thus an exciting therapeutic target for diabetes, metabolic syndrome, atherosclerosis, and cancer. Unexpectedly, genetic studies performed in mice established that PPARγ are essential for placental development. After a brief description of structural and functional features of PPARs, we will summarize in this review the most recent results concerning expression and the role of PPARs in placenta and of PPARγ in human trophoblastic cells in particular.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Placenta - Volume 28, Issues 2–3, February–March 2007, Pages 65–76
نویسندگان
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