کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2789903 | 1154533 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Contribution of Potassium in Human Placental Steroidogenesis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
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چکیده انگلیسی
The role of K+ on steroidogenesis in isolated mitochondria from the human placenta was explored. Cholesterol uptake and progesterone synthesis were stimulated by K+, and by the further addition of ATP. In the presence of glibenclamide or quinine (inhibitors of the K+ channel mito-KATP), the synthesis of progesterone was improved, indicating that K+ acts outside the mitochondria. Valinomycin, a K+-ionophore, inhibited mitochondrial steroidogenesis only in the absence of K+. The mitochondrial K+ channel in human placental mitochondria is formed by the subunit Kir 6.1 which was detected by Western blot with polyclonal antibodies. These results suggest that K+ contributes placental mitochondrial steroidogenesis facilitating cholesterol uptake and intermembrane translocation through a mechanism non-dependent of the transport of K+ inside the mitochondria.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Placenta - Volume 31, Issue 10, October 2010, Pages 860-866
Journal: Placenta - Volume 31, Issue 10, October 2010, Pages 860-866
نویسندگان
R. Milan, O. Flores-Herrera, M.T. Espinosa-Garcia, S. Olvera-Sanchez, F. Martinez,