کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2789913 1154533 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reduced allele specific annexin A5 mRNA levels in placentas carrying the M2/ANXA5 allele
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Reduced allele specific annexin A5 mRNA levels in placentas carrying the M2/ANXA5 allele
چکیده انگلیسی

We aimed to trace the allele specific expression of ANXA5 mRNA in placentas carrying the M2 haplotype, conferring higher recurrent pregnancy loss risk, in order to verify directly the role of M2 in the relevant organ. The M2 allele in heterozygous placentas results in an average of 42% reduced ANXA5 mRNA levels as compared to the normal allele. Protein levels in these samples show considerable variations, impossible for statistical interpretation. The M2 allele of ANXA5 can be linked to reduced mRNA levels in heterozygous placentas and could result in more confined protein levels (lowered expression dynamics) of annexin A5.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Placenta - Volume 31, Issue 10, October 2010, Pages 937–940
نویسندگان
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