کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2790082 1154542 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Designing Pregnancy Centered Medications: Drugs Which Do Not Cross the Human Placenta
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Designing Pregnancy Centered Medications: Drugs Which Do Not Cross the Human Placenta
چکیده انگلیسی

This review considers and evaluates the role of placental transporters (multidrug resistance proteins, P-glycoprotein and breast cancer resistance protein) in the uptake and efflux of drugs used in pregnancy. The effect of placental transporters in effluxing drugs such as glyburide and numerous protease inhibitors from the fetal circulation offers the potential to manipulate the passage of drugs across the placenta. The discovery of the interactions of these drugs with placental transporters may provide a novel framework for future drug development in which medications can be designed to control the degree of fetal exposure and thus prevent fetal risk.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Placenta - Volume 27, Issue 8, August 2006, Pages 861–868
نویسندگان
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