کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2790375 1568580 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Placental Deficiency of Interleukin-10 (IL-10) in Preeclampsia and its Relationship to an IL10 Promoter Polymorphism
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Placental Deficiency of Interleukin-10 (IL-10) in Preeclampsia and its Relationship to an IL10 Promoter Polymorphism
چکیده انگلیسی

The placenta is pivotal in the acceptance of the feto-placental unit by the maternal immune system. Imbalance at the maternal–fetal interface of tissue pro- and anti-inflammatory cytokines may be partly involved in disease causation. Previous work has shown conflicting levels of IL-10. IL-10 levels have been shown to increase, decrease, or remain unchanged in women with preeclampsia. This study examines the difference in serum and placental IL-10 expression in women with preeclampsia and investigates if the IL10 (−1082) A promoter polymorphism contributes to lower concentrations. In a prospective case–control study of 12 women with preeclampsia and 31 controls we assessed serum IL-10 by ELISA, placental mRNA by quantitative PCR and protein by immunohistochemistry as well as placental IL10 promoter genotype. Comparisons were made with non-parametric tests where necessary and chi-square. We found a significant reduction in placental IL-10 mRNA and protein expression in women with preeclampsia compared to controls. Women with the AA IL-10 promoter genotype expressed less placental IL-10 mRNA compared to women with AG or GG genotype. There was no difference in serum IL-10 concentrations between different genotypes. Preeclampsia is associated with a deficiency of placental IL-10. Placental AA genotype in the promoter region results in significantly less placental IL-10.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Placenta - Volume 27, Issues 4–5, April–May 2006, Pages 445–451
نویسندگان
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