کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2791316 1154866 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lines of mice with chronically elevated baseline corticosterone levels are more susceptible to a parasitic nematode infection
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Lines of mice with chronically elevated baseline corticosterone levels are more susceptible to a parasitic nematode infection
چکیده انگلیسی

Chronically elevated circulating plasma glucocorticoid concentrations can have suppressive effects on immune function in mammals. House mice (Mus domesticus) that have been selectively bred for high voluntary wheel running exhibit chronically elevated (two-fold, on average) plasma corticosterone (CORT) levels and hence are an interesting model to study possible glucocorticoid-induced immune suppression. As an initial test of their immunocompetence, we compared the four replicate high runner (HR) lines with their four non-selected control (C) lines by subjecting them to infection by a parasitic nematode, Nippostrongylus brasiliensis. At generation 36 of the selection experiment, 10 adult males from each of the eight lines were inoculated subcutaneously with approximately 600 third-stage larval N. brasiliensis, and then sacrificed 12 days after injection. Neither spleen mass nor number of adult nematodes in the small intestine differed significantly between HR and C lines. However, the eight lines differed significantly in nematode counts, and the line means for nematode infestation were significantly positively related to baseline circulating CORT concentration measured in males from generations 34 and 39. Therefore, although selective breeding for high locomotor activity may not have resulted in a generally compromised immune response, results of this study are consistent with the hypothesis that glucocorticoids can have immunosuppressive effects.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Zoology - Volume 112, Issue 4, 15 July 2009, Pages 316–324
نویسندگان
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