کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2792299 | 1568667 | 2016 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Genetic determinism of bone and mineral metabolism in meat-type chickens: A QTL mapping study Genetic determinism of bone and mineral metabolism in meat-type chickens: A QTL mapping study](/preview/png/2792299.png)
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• The genetic basis of bone and mineral metabolism is investigated in a QTL detection study in meat-type chickens.
• Thirty-five QTL were identified for tibia weight, size, strength and mineralization, plasma P concentration and P retention.
• Six QTL were genome-wide significant.
• Three QTL for tibia relative volume, weight and ash weight on chromosome 6 were fixed.
• These findings support the evidence of multiple genetic loci controlling bone and mineral metabolism.
Skeletal integrity in meat-type chickens is affected by many factors including rapid growth rate, nutrition and genetics. To investigate the genetic basis of bone and mineral metabolism, a QTL detection study was conducted in an intercross between two lines of meat-type chickens divergently selected for their high (D +) or low (D −) digestive efficiency. Tibia size (length, diameter, volume) and ash content were determined at 3 weeks of age as well as phosphorus (P) retention and plasma concentration. Heritability of these traits and their genetic correlations with digestive efficiency were estimated. A QTL mapping study was performed using 3379 SNP markers.Tibia size, weight, ash content and breaking strength were highly heritable (0.42 to 0.61). Relative tibia diameter and volume as well as P retention were strongly and positively genetically correlated with digestive efficiency (0.57 to 0.80).A total of 35 QTL were identified (9 for tibia weight, 13 for tibia size, 5 for bone strength, 5 for bone mineralization, 2 for plasma P concentration and 1 for P retention). Six QTL were genome-wide significant, and 3 QTL for tibia relative volume, weight and ash weight on chromosome 6 were fixed, the positive allele coming from the D-line. For two QTL for ash content on chromosome 18 and relative tibia length on chromosome 26, the confidence intervals were small enough to identify potential candidate genes.These findings support the evidence of multiple genetic loci controlling bone and mineral metabolism. The identification of candidate genes may provide new perspectives in the understanding of bone regulation, even beyond avian species.
Journal: Bone Reports - Volume 5, December 2016, Pages 43–50